Assessing prognosis in metastatic pancreatic cancer by the serum tumor marker CA 19-9: Pretreatment levels or kinetics during chemotherapy?

Background: The carbohydrate antigen 19-9 (CA 19-9) is currently the most widely used serum tumor marker in pancreatic cancer (PC). CA 19-9 pretreatment levels as well as CA 19-9 kinetics during systemic chemotherapy can provide prognostic information regarding survival of patients with metastatic PC. Case Reports: We report the clinical course of 2 patients with metastatic PC who underwent palliative chemotherapy with gemcitabine. Both patients showed a significant elevation of pretreatment CA 19-9 levels (7,505 and 150,000 U/ml, respectively), however, subsequently they experienced a highly significant reduction (> 90%) of CA 19-9 kinetics under gemcitabine chemotherapy. A good disease control and a clinical benefit response were achieved in both patients. Time to tumor progression was 30 weeks and 28 weeks, overall survival 14 months and 11 months, respectively. Conclusion: These data indicate that CA 19-9 kinetics under chemotherapy may possibly serve as a useful surrogate marker for time to tumor progression and survival in advanced PC

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling

The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly due to the large amounts of BMP2 applied. Therefore, reduction of BMP2 amounts while maintaining efficacy is of clinical importance. As nitric oxide (NO) signaling plays a role in bone fracture healing and an association with the BMP2 pathway has been indicated, this study aimed to investigate the relationship of BMP2 and NO pathways and whether NO can enhance BMP2-induced signaling and osteogenic abilities in vitro. To achieve this, the stable BMP reporter cell line C2C12BRELuc was used to quantify BMP signaling, and alkaline phosphatase (ALP) activity and gene expression were used to quantify osteogenic potency. C2C12BRELuc cells were treated with recombinant BMP2 in combination with NO donors and substrate (Deta NONOate, SNAP & L-Arginine), NOS inhibitor (LNAME), soluble guanylyl cyclase (sGC) inhibitor (LY83583) and activator (YC-1), BMP type-I receptor inhibitor (LDN-193189), or protein kinase A (PKA) inhibitor (H89). It was found that the NOS enzyme, direct NO application, and sGC enhanced BMP2 signaling and improved BMP2 induced osteogenic activity. The application of a PKA inhibitor demonstrated that BMP2 signaling is enhanced by the NO pathway via PKA, underlining the capability of BMP2 in activating the NO pathway. Collectively, this study proves the ability of the NO pathway to enhance BMP2 signaling

Societal Expectations on Structural Change in Agriculture: How can the Sector Cope with it?

In Germany, productivity gains and other factors induce structural changes in agriculture since decades. While the number of farms decreases simultaneously average farm sizes with respect to area and herd sizes increases. Conflicts between agricultural reality and society’s perception will always surface when production methods of large farms become public and significantly divert from the societal expectations mainly if the society still have romantic views from story-books in their mind. In this study societal perception of structural change in agriculture is analyzed using a mixed method approach to identify the main conflicts and to evaluate options to cope with these. In the focus group discussions as well as in the online survey a rejecting or critical attitude towards structural change in agriculture was stated. Structural change in agriculture was often associated with ‘mass production’, ‘mechanization’ or ‘agrarian factories’. Participants requested a restructuring of agriculture towards smaller and more diversified farms; however, most are aware that the technical progress require also adjustments in the agriculture. As expected, results do not provide an easy solution to cope with societal expectations. Responsibility for a better alignment of structural change to societal expectations is seen multi-layered: The government, the farmers, the processing industry as well as the consumers seem to be in demand

Preferences for School Milk - How Juveniles Differ

Snacks and lunches offered at school can decisively influence children’s dietary habits. In the light of discussions to establish prevention and intervention programs to abate current trends of rising childhood obesity, children’s preferences for food items with lower calorie content gain on importance. But youths preferences concerning different school milk products are not well-known. Therefore, the objective is to investigate if the milk products offered at school still meet older children’s preferences or if modifications could prove to be useful. Based on outcomes of an online survey covering a choice experiment and conducted among juveniles in Germany the probability that youths benefit from different products as well as varying prices, sugar and fat contents is estimated. Socio-demographics, psycho-metrics and perceived weight status are employed to explain youths choices preferring novel school milk products yet unavailable in German schools. Results of the choice experiment show that youths aged 15-18 are a heterogeneous group. They prefer a wider range of different products including drinking yoghurt as an option as well. Results indicate that nutritional aspects (low sugar/fat content, artificial sweetener) and body image are important for some of them

What is the benefit of organically-reared dairy cattle? Societal perception towards conventional and organic dairy farming

During the last years, current systems in agriculture and food production have been topic in public discussions. Especially modern animal husbandry seems not to match consumers’ or societal needs any longer. This paper concentrates on the society’s perspective regarding dairy farming in general and diverting perceptions and expectations with respect to dairy cattle either reared organically or reared conventionally. It aims to give orientation to farmers as well as policymakers about the societal point of view of dairy farming.Six focus groups were carried out in three German cities to capture the scope of opinions and expectations among the population. Three of those groups consisted of participants buying mainly organic food while the other three comprised citizens buying mainly conventional food.With respect to society’s perception of today’s dairy farming results showed that participants put emphasis on the following topics: the space for each cow was considered as insufficient and not species-appropriate, assumed application of medications as too high, and in particular the prophylactic use of antibiotics as problematic.Asked about perceived differences between organic versus conventional farming it became obvious that organic in contrast to the conventional farming was perceived as more species-appropriate. More or less, all previously criticized aspects seem to be regarded as irrelevant in organic farming. Some participants showed a very romantic view of organic dairy farming. The most critical point was an assumed high rate of rogue traders among organic farmers

Does everyone reject modern pig production? Identification and characterisation of societal groups in Germany

Today’s agriculture and food production has been topic in public discussions and the media in the last years. Societal perceptions and imaginations of agriculture seem to be far away from reality. There is no indication of a declining gap between consumers’ expectations and their perception of animal husbandry. However, precise information about expectations and priorities of the population are unknown. Thus, the paper concentrates on society’s views and opinions. On the example of intensive pig production, the objective of the study is to analyse societal perceptions, expectations and main points of criticism. It also aims on the identification and characterisation of societal groups with almost identical attitudes.By combining exploratory focus groups with a quantitative survey, a mixed method approach is pursued. Focus groups are carried out in September 2012 in three German cities to capture a variety of opinions and concerns among the population. On the basis of findings from focus groups a quantitative survey is carried out in spring 2013 per online survey with approximately 1500 German citizens to quantify qualitative results.The surveys’ findings confirmed many of the critical views gained in the focus groups. On the basis of four extracted attitudinal factors three groups with heterogeneous opinions are differentiated with respect to modern pig production. Besides a very engaged group which is characterised by a strong criticism in general and a strong critical perception of current production systems, also a considerable group accepting modern animal husbandry was identified. The multinomial logit regression finally allows for a characterisation of the identified societal segments by sociodemographic and regional aspects. Additionally, the question of responsibility and the acceptance of consequences of several governmental actions are included in the model. It turns out that gender and agricultural knowledge of the people are significant determinants in explaining cluster membership. Interestingly, opponents more often have a good knowledge of agriculture. These findings imply that negative attitudes cannot be traced back to a missing knowledge

What is the benefit of organically-reared dairy cattle? Societal perception towards conventional and organic dairy farming

During the last years, current systems in agriculture and food production have been topic in public discussions. Especially modern animal husbandry seems not to match consumers’ or societal needs any longer. This paper concentrates on the society’s perspective regarding dairy farming in general and diverting perceptions and expectations with respect to dairy cattle either reared organically or reared conventionally. It aims to give orientation to farmers as well as policymakers about the societal point of view of dairy farming.Six focus groups were carried out in three German cities to capture the scope of opinions and expectations among the population. Three of those groups consisted of participants buying mainly organic food while the other three comprised citizens buying mainly conventional food.With respect to society’s perception of today’s dairy farming results showed that participants put emphasis on the following topics: the space for each cow was considered as insufficient and not species-appropriate, assumed application of medications as too high, and in particular the prophylactic use of antibiotics as problematic.Asked about perceived differences between organic versus conventional farming it became obvious that organic in contrast to the conventional farming was perceived as more species-appropriate. More or less, all previously criticized aspects seem to be regarded as irrelevant in organic farming. Some participants showed a very romantic view of organic dairy farming. The most critical point was an assumed high rate of rogue traders among organic farmers